Gestational Trophoblastic Diseases (GTD) During Pregnancy

Gestational trophoblastic disease, or GTD as it is more commonly known, is a group or rare tumors that leads to the abnormal growth of cells within a woman’s uterus. Unlike cervical or endometrial cancer, GTD does not develop from cells of the uterus.

However, the tumors tend to start in the cells that would normally form the placenta during pregnancy.


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Conditions in Gestational trophoblastic disease during Pregnancy

The condition will first start in a layer of cells known as the trophoblast that surround the embryo. During the initial stages of its development, the cells of this layer will form tiny, finger like projections that grow into the lining of the uterus.

It is important to remember that not all the GTD’s are necessarily cancerous as most of them tend to be benign. There are a number of types of GTD’s such as hydatidiform mole, persistent gestational trophoblastic disease and Invasive mole among others. The hydatidiform mole is probably the most common occurrence out of all the GTD’s and are actually the finger like projections in the uterine lining that become swollen with fluid. When they swell up together, they may appear to resemble a bunch of grapes. When affected by this condition, the baby will not form normally and, even though the moles are benign, they may develop into cancerous forms of GTD.

Treatment for GTD or Gestational trophoblastic disease during pregnancy

Most conditions of GTD are cured with the help of surgery.

However, if the condition is not resolved with this, it is considered to be persistent gestational trophoblastic disease. The initial surgery that is used will normally involve scrapping the inside of the uterus, but if the tumor has grown deep into the muscular wall, this may be quite difficult. An invasive mole is a type of hyatidiform mole that develop in a little less than 1 out of every 5 women that are affected by GTD’s.

Some women are at a greater risk of this development if there is a significantly long period of time between two menstrual periods, the woman is above the age of 40, has been affected by a GTD in the past or even if the uterus has, for some reason or the other, become very large. About 15% of all invasive moles will spread to other parts of the body – the most frequent site of attack being the lungs. Placental site trophoblastic tumor is probably the rarest type of GTD around. It develops when the placenta attaches to the uterus and is more likely to develop after a normal pregnancy or abortion.

What is GTD During Pregnancy?
Gestational Trophoblastic Diseases During Pregnancy
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